Fw: [SOC] Second class drink of water -

[Paul Bartlett]

Twas tounge in cheek ;-)

Unless you are familiar with the biochemical pathways (and that includes
me!) then it is complete gobbledegook.

Paul

----- Original Message -----
From: "Reicher, James" <JReicher at hrblock.com>
To: "Second Class Operators' Club" <soc at mailman.qth.net>
Sent: Monday, August 30, 2004 2:49 PM
Subject: RE: Fw: [SOC] Second class drink of water -


Could someone please put that into ordinary English?

It's Monday morning here, I got loaded last night, having watched my
favorite football team (real American football, with armor and helmets!
Not that stuff with the knee socks, etc.), the Chiefs lose.  OK, so the
game was Saturday night.  I'm heartbroken.  Caffeine has not yet kicked
in and my head is pounding.

73 de N8AU, Jim in Raymore, MO

-----Original Message-----
From: soc-bounces at mailman.qth.net [mailto:soc-bounces at mailman.qth.net]
On Behalf Of Bob Nielsen
Sent: Monday, August 30, 2004 5:38 AM
To: Second Class Operators' Club
Subject: Re: Fw: [SOC] Second class drink of water -

Do you feel a need to point out the obvious?

On Mon, Aug 30, 2004 at 11:15:05AM +0100, Paul Bartlett wrote:
> >From my brother Kim - Professor of clinical biochemistry
>
> P ;-)
>
>
> ----- Original Message -----
> From: "Kim Bartlett" <k.bartlett at golduk.net>
> To: "Paul Bartlett" <paul at fulking.freeserve.co.uk>
> Sent: Friday, August 27, 2004 2:01 PM
> Subject: RE: [SOC] Second class drink of water -
>
>
> > RE: turbo etc
> >
> > Truth may be stranger than fiction...
> >
> > See below:
> >
> > The first step in caspase activation is transition of the latent
zymogen
> to
> > an active form. For the initiator caspases, this occurs through
> dimerization
> > of monomeric zymogens at an activating complex. Recent studies have
> > suggested that FLIPL [FLICE-like inhibitory protein, long form;
FLICE is
> > FADD (Fas-associated death domain protein)-like
interleukin-1b-converting
> > enzyme], previously thought to act solely as an inhibitor of
caspase-8
> > activation, can under certain circumstances function to enhance
caspase
> > activation. Using an in vitro induced-proximity assay, we
demonstrate that
> > activation of caspases-8 and -10 occurs independently of cleavage of
> either
> > the caspase or FLIPL. FLIPL activates caspase-8 by forming
heterodimeric
> > enzyme molecules with substrate specificity and catalytic activity
> > indistinguishable from those of caspase-8 homodimers. Significantly,
the
> > barrier for heterodimer formation is lower than that for homodimer
> > formation, suggesting that FLIPL is a more potent activator of
caspase-8
> > than is caspase-8 itself.
> >
> > This is actually a v. v. v. v. important study!!
> >
> > K
> >
>
>