Fw: [SOC] Second class drink of water -

[Bob Nielsen]

Do you feel a need to point out the obvious?

On Mon, Aug 30, 2004 at 11:15:05AM +0100, Paul Bartlett wrote:
> >From my brother Kim - Professor of clinical biochemistry
> 
> P ;-)
> 
> 
> ----- Original Message -----
> From: "Kim Bartlett" <k.bartlett at golduk.net>
> To: "Paul Bartlett" <paul at fulking.freeserve.co.uk>
> Sent: Friday, August 27, 2004 2:01 PM
> Subject: RE: [SOC] Second class drink of water -
> 
> 
> > RE: turbo etc
> >
> > Truth may be stranger than fiction...
> >
> > See below:
> >
> > The first step in caspase activation is transition of the latent zymogen
> to
> > an active form. For the initiator caspases, this occurs through
> dimerization
> > of monomeric zymogens at an activating complex. Recent studies have
> > suggested that FLIPL [FLICE-like inhibitory protein, long form; FLICE is
> > FADD (Fas-associated death domain protein)-like interleukin-1b-converting
> > enzyme], previously thought to act solely as an inhibitor of caspase-8
> > activation, can under certain circumstances function to enhance caspase
> > activation. Using an in vitro induced-proximity assay, we demonstrate that
> > activation of caspases-8 and -10 occurs independently of cleavage of
> either
> > the caspase or FLIPL. FLIPL activates caspase-8 by forming heterodimeric
> > enzyme molecules with substrate specificity and catalytic activity
> > indistinguishable from those of caspase-8 homodimers. Significantly, the
> > barrier for heterodimer formation is lower than that for homodimer
> > formation, suggesting that FLIPL is a more potent activator of caspase-8
> > than is caspase-8 itself.
> >
> > This is actually a v. v. v. v. important study!!
> >
> > K
> >
> 
>