Please see below:

It is extremely important that if you are operating a hotspot on SkyHubLink when in YSF mode that you DO NOT enable WIRES-X Passthrough.  DO NOT operate your radio in Wires-X mode to change reflectors when connected to SkyHubLink.  DO use the web interface of your Pi-Star or hotspot to change reflectors.  If you operate with YSF Passthrough and control the Pi-Star with your radio while on the US-SKYHUBLINK reflector 92722 it can then cause disconnects and link issues.  PLEASE DO NOT use this feature of your hotspot when connected to SKYHUBLINK!